Aliskiren inhibits renin-mediated complement activation
نویسندگان
چکیده
منابع مشابه
Aliskiren: A Novel, Orally Active Renin Inhibitor
Renin-angiotensin-aldosterone systems play a major role in the regulation of human homeostasis mechanism, which are also involved in the development of hypertension and end-organ damage through activation of angiotensin II. Inhibitors of the renin-angiotensin-aldosterone system may reduce the development of end-organ damage to a greater extent than other antihypertensive agents. Aliskiren is th...
متن کاملDirect renin inhibition: focus on aliskiren.
BACKGROUND Despite the availability of many effective, well-tolerated drugs, a significant proportion of treated hypertensive patients still have uncontrolled high blood pressure (BP) and thus face serious morbidity and mortality. The renin-angiotensin aldosterone system (RAAS) is a key target for BP control and for cardiovascular and renal protection. Renin controls the rate-limiting step in t...
متن کاملMonomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin.
Previous studies have shown that complement activation on renal tubular cells is involved in the induction of interstitial fibrosis and cellular injury. Evidence suggests that the tubular cell damage is initiated by the alternative pathway (AP) of complement with properdin having an instrumental role. Properdin is a positive regulator of the AP, which can bind necrotic cells as well as viable p...
متن کاملRenin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy
Hypertension is a major risk factor for the development of cardiovascular and renal disease. The incidence of hypertension is increasing globally and the rate of blood pressure control remains inadequate. Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in volume regulation and maintenance of blood pressure. Pathological activation of RAAS results in chronic hypertension and con...
متن کاملdirect renin inhibitor: aliskiren in chronic kidney disease
the renin-angiotensin-aldosterone system (raas) plays pivotal roles in the pathogenesis of chronic kidney disease (ckd) progression and its increased complications such as hypertension (ht) and cardiovascular diseases (cvd). previous studies suggested that aliskiren a direct renin inhibitor, blocks raas and may be effective for the management of ckd and its complications. this review focuses on...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2018
ISSN: 0085-2538
DOI: 10.1016/j.kint.2018.04.004